Comment on 'Discrepancies in dbSNP confirmations rates and allele frequency distributions from varying genotyping error rates and patterns'.
نویسندگان
چکیده
frequency distributions from varying genotyping error rates and patterns” Christopher S. Carlson, Michael A. Eberle, Mark J. Reider, Leonid Kruglyak and Deborah A. Nickerson Department of Genome Sciences, University of Washington, 1705 NE Pacific, Seattle, Washington 98109. Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue N, Seattle, Washington 98109. Howard Hughes Medical Institute, Chevy Chase, Maryland.
منابع مشابه
Discrepancies in dbSNP confirmation rates and allele frequency distributions from varying genotyping error rates and patterns
SUMMARY Three recent publications have examined the quality and completeness of public database single nucleotide polymorphism (dbSNP) and have come to dramatically different conclusions regarding dbSNPs false positive rate and the proportion of dbSNPs that are expected to be common. These studies employed different genotyping technologies and different protocols in determining minimum acceptab...
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متن کاملAssessing the impact of non-differential genotyping errors on rare variant tests of association.
BACKGROUND/AIMS We aim to quantify the effect of non-differential genotyping errors on the power of rare variant tests and identify those situations when genotyping errors are most harmful. METHODS We simulated genotype and phenotype data for a range of sample sizes, minor allele frequencies, disease relative risks and numbers of rare variants. Genotype errors were then simulated using five d...
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ورودعنوان ژورنال:
- Bioinformatics
دوره 21 2 شماره
صفحات -
تاریخ انتشار 2005